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testing chamber by the experimenter after every intromission In this way, Larsson was able to vary the time between intromissions and found that male intromission intervals that lasted longer than normal resulted in males that learned to ejaculate with far fewer intromissions One of the interpretations of this data was that the imposition of longer intromission intervals made males more sympathetically aroused, and led to either a faster ejaculation or one that required less tactile penile stimulation This model of hyperstimulation of sympathetic out ow by either highly stimulating, unpredictable, or stressful sex, formed part of the basis of Masters and Johnson s model of premature ejaculation a decade later Despite this, the model has not been developed further, nor has it been used widely to examine drug effects More recently it was reported that natural differences are found in the ejaculation latencies of male rats, which may indicate a more biological explanation of premature ejaculation that shares some of the characteristics of human premature ejaculation In pooled populations of male albino Wistar rats during a 30 min standardized mating test, three categories of males were identi ed: (1) males that displayed a low number of ejaculations (0 to1) and were considered as sexually sluggish or hypo-sexual ; (2) a second category of rats that showed a range of two or three ejaculations and were considered as normal ejaculators; and (3) males who displayed four or ve ejaculations and were considered as rapid ejaculators or hypersexual rats The number of ejaculations across the various studies was distributed according to a Gaussian curve: on one side approximately 10% of rats display hypo-sexual behavior and on the other side 10% display hyper-sexual behavior after at least four successive weekly sexual tests of 30 min Interesting differences were found between the sluggish and rapid groups of rats with regard to a variety of other parameters of sexual behavior, resembling clinical symptoms of men suffering from retarded and premature ejaculation, respectively The hyper-sexual animals have been further investigated in order to know whether they could be used as a model for human premature ejaculation Compared to normal ejaculators, ejaculation. rdlc pdf 417 PDF417 Barcode Creating Library for RDLC Reports | Generate ...
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Free trial package available to insert PDF - 417 barcode image into Client Report RDLC . 1 sent during their early sexual experience For example, a sizable proportion (often nearly 50%) of male rats will not copulate during their rst trial with sexually receptive females unless they are pre-exposed to the testing chamber Indeed, a large proportion of these noncopulators will never copulate, despite repeated exposure to receptive females Novel environments are stressful to male rats, and induce the activation of endogenous opioids Treatment with the opioid antagonist naloxone can reverse this novelty-induced stress effect Another way to study hypoactive desire in male rats is to examine their sexual responsiveness following multiple ejaculations, a phenomenon known as sexual exhaustion Male rats are able to ejaculate several times before becoming unresponsive During this period of sexual activity, there is a progressive increase in the post-ejaculatory refractory period consonant, with a decrease in the number of intromissions before each ejaculation and a lengthening of the interintromission interval (a state that suggests a progressive loss of erectile function as the number of ejaculations increases) After males become sexually exhausted, they remain unresponsive to female solicitations for up to 72 hrs RodriguezManzo and colleagues have examined the ability of several classes of drug to increase the responsiveness of these males, including the opioid antagonist naloxone, 8-OH-DPAT, and the 2 presynaptic autoreceptor antagonist yohimbine Only yohimbine increased the proportion of males that mounted, intromitted, and displayed an ejaculatory-like behavioral pattern (but without seminal emission), suggesting that a decline in adrenergic activity is an important component of inhibited sexual desire in males rdlc pdf 417 How to add Barcode to Local Reports ( RDLC ) before report ...
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Barcode Control SDK supports generating Data Matrix, QR Code, PDF - 417 barcodes in RDLC Local Report using VB and C# class library both in ASP.NET and ... Dial /25 8 /24 /28 latency was shorter in rapid ejaculators and longer in sluggish ejaculators Intromission and mount frequencies, the latter being considered as a putative index of sexual motivation, did not differ between the three categories of ejaculators, suggesting no differences in appetitive components of sexual behavior When investigating the effects of 8-hydroxy2-di-n-propylamino-tetralin (8-OH-DPAT) in these three categories of males, this compound was shown to induce a statistically signi cant increase in the number of ejaculations displayed by sluggish and normal rats, and to decrease in a statistically signi cant way the ejaculation latency in the sluggish , normal and rapid rats This experimental paradigm, despite the fact it has been recently reported and not yet con rmed by others, appears as extremely attractive Indeed hyper-sexual rats likely represent a pathophysiologic model of premature ejaculation It remains to be seen whether drugs that can counteract premature ejaculation in men can increase the latency of male rats to ejaculate in this condition It also remains to be studied whether such males are uniquely susceptible to an enforced interval effect
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